The drug-interaction graph the world builds together.
A free, proof-carrying drug-interaction reference. Every relationship shows the exact FDA-label sentence it came from — and when a pair isn't in the label, it abstains out loud rather than guess a pair is safe.
Never-launder
An answer carries its cited FDA-label span, or it abstains. Zero fabricated relationships — enforced by the same gate that builds the graph.
The citation is the answer
Every relationship is its proof: the SPL SET_ID, the LOINC section, and the verbatim label sentence — auditable, not a black box.
Open & verifiable
MIT over FDA public-domain labels; export CSV / JSON-LD / FHIR / RDF. Regenerated from tests — yours to check.
Powered by NuSy
A neurosymbolic engine: an LLM proposes, a symbolic gate disposes, and only proof-carrying relationships are served.
Search a drug to begin
- Interaction
- Contraindication
- Search a drug to list its cited relationships.
Medication Safety Check
A guideline recommends a drug — but is it safe against what the patient already takes? Enter a candidate drug and the patient's active medications. A cited interaction withholds the recommendation with its FDA-label proof; an unknown drug abstains loudly; no cited interaction recommends (open-world — “no cited interaction found”, never “proven safe”).
Measures
Review queue
Community contributions awaiting confirmation. Two independent confirmations mark a contribution ready to promote — and the citation is the gate: a contribution with no source is Blocked and can never enter the graph.Recent changes
Every submission and status change, in the open — like a wiki, not a git log. Pick a relationship to see its full timeline.Not a maintained table — a live reasoner over a proof-carrying graph.
Every OpenDrugGraph answer is computed by a neurosymbolic engine: a language model proposes, a symbolic gate disposes, and the result is either Proven with a full provenance trace, Heuristic (clearly labelled), or a loud abstention. The same open-source engine — NuSy — runs guideline CDS, terminology, and any domain where a wrong answer is unacceptable.
The engine, by mechanism
Each is real, open code — not a slogan.An LLM proposes; a symbolic gate decides. Every answer is Proven / Heuristic / Abstain, computed from a proof trace — never set. nusy-reasoner · Provability
No relationship enters the graph without a complete FDA-label citation + verified codes, or it is flagged. nusy-drug-graph · emit::gate_edge
drug→enzyme/transporter links + forward-chaining derive interactions a pair-table cannot hold. nusy-forward-chain · proof.rs
The graph is columnar Arrow / Parquet — fast to query, and exportable as CSV, JSON-LD, FHIR, and Turtle. nusy-arrow-core
Every relationship ships a Given/When/Then competency question and promotes only by passing it. nusy-kbdd · competency_question
Every change — by anyone, any role — is cited, logged, and reversible into review. nusy-provenance-ledger
Every answer is a data structure you can inspect
Representative response shape — GET /api/edge/:id over the live graph.OpenDrugGraph is one instance of a general engine.
The same proof-carrying, never-launder reasoning runs guideline CDS, clinical terminology, and any regulated-domain decision support. The reasoners are MIT-licensed and open — build on them, or have us build your domain.
Needs work
The AI proposes cited interactions from FDA labels; humans verify them and fill the gaps. These are the drugs whose must-not-miss interactions are still missing — highest-harm gaps first.
The prioritized queue
avoid/modify gaps first, least-complete first · click a column to re-sortWanted List
The most-prescribed drugs that have no cited interaction yet, in prescription-volume order. Pick one and add a cited interaction — every contribution shrinks the gap toward the coverage north-star.
Download the graph
The entire proof-carrying drug-interaction graph, free and MIT-licensed, in machine-readable formats. Every export carries only cited edges — the never-launder honesty tally (skipped_uncited) and the licence tally (skipped_license) are shown per format so you can audit the open-data claim yourself. Browsing is open; downloading requires a free sign-in.
Reference catalog
A citable dataset DOI (Zenodo) and downloadable OWL/SHACL shapes for self-verification are planned — until an artifact is actually published we show it as coming, never a dead link. See /api/download/formats for the live, authoritative manifest.